Fig. 1
From: To Mia or not to Mia: stepwise evolution of the mitochondrial intermembrane space disulfide relay
Stepwise evolution of the mitochondrial IMS disulfide relay. Displayed are the disulfide relay systems from three selected species, demonstrating the three potential phases of the stepwise evolution. Firstly, an Erv1-only relay as observed in Trypanosoma brucei. Secondly, a relay containing a Mia40 that is dispensable as observed in Arabidopsis thaliana. Thirdly, a relay with both an essential Mia40 and Erv1 as observed in Homo sapiens. Indicated for all organisms are the structural domain organization and the pairs of cysteine’s required for correct function of Erv1. Also indicated are the c-type cytochrome maturation pathways which function within each species