Fig. 2.
From: Q&A: Trash talk: disposal and remote degradation of neuronal garbage
Higher proteostress and impaired mitochondrial quality increase exopher formation. When proteostasis and mitochondrial quality are compromised through protein misfolding, inhibited proteasome function, and/or impaired autophagy and mitophagy, increased protein aggregates and damaged mitochondria are generated and numbers of observed exopher extrusions rise. The suggestion is that increased trash load results in increased external garbage disposal