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Fig. 4 | BMC Biology

Fig. 4

From: Altering cortical input unmasks synaptic phenotypes in the YAC128 cortico-striatal co-culture model of Huntington disease

Fig. 4

YAC128 MSNs co-cultured at 1:1 exhibit an impaired increase in membrane capacitance with maturation. (a) Representative recording traces from WT and YAC128 MSNs in 1:1 or 1:3 co-culture at DIV14 and 21. (Bi, Bii) mEPSC frequency and (Ci, Cii) membrane capacitance (Cm) tend to increase with maturation, but a significant genotypic difference was only observed for Cm at DIV21 in 1:1 cultures [n = 12–29(3); two-way ANOVA with Bonferroni post-hoc analysis; *p < 0.05]

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BMC Biology

ISSN: 1741-7007

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