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Table 4 Inhibition percentage of capillary tube formation, viability, and invasiveness of endothelial TIME cells growing on Matrigel vs FL-Ang1-treated controls

From: Targeting the Tie2–αvβ3 integrin axis with bi-specific reagents for the inhibition of angiogenesis

Inhibitor Inhibition of tube formation* Reduction in endothelial cell viability** Inhibition of invasiveness*
Reduction in no. of tubular meshes Reduction in no. of tubular junctions
Bi-specific
 Ang2-BDBC5 38 38 30 60
 Ang2-BDBC6 37 26 34 40
 Ang2-BDBC10 50 38 36 49
Mono-specific
 Ang2-BDWT 16 20 15 28
 cRGD peptide 28 20 17 30
  1. *Inhibitor concentration 1 μM
  2. **Inhibitor concentration 2 μM