Table 4 Inhibition percentage of capillary tube formation, viability, and invasiveness of endothelial TIME cells growing on Matrigel vs FL-Ang1-treated controls
From: Targeting the Tie2–αvβ3 integrin axis with bi-specific reagents for the inhibition of angiogenesis
Inhibitor | Inhibition of tube formation* | Reduction in endothelial cell viability** | Inhibition of invasiveness* | |
|---|---|---|---|---|
Reduction in no. of tubular meshes | Reduction in no. of tubular junctions | |||
Bi-specific | ||||
Ang2-BDBC5 | 38 | 38 | 30 | 60 |
Ang2-BDBC6 | 37 | 26 | 34 | 40 |
Ang2-BDBC10 | 50 | 38 | 36 | 49 |
Mono-specific | ||||
Ang2-BDWT | 16 | 20 | 15 | 28 |
cRGD peptide | 28 | 20 | 17 | 30 |