Skip to main content
Fig. 3 | BMC Biology

Fig. 3

From: Migration through a small pore disrupts inactive chromatin organization in neutrophil-like cells

Fig. 3

Compartment switching following migration with or without constriction. a Compartment structure is mostly conserved, with a small proportion of regions in different compartments in cells migrated with or without constriction. 100 kb bins were considered switched if they had the opposite PC1 sign and low correlation (R < 0.6) between the two conditions. b Bootstrapping found that switching from compartment B occurred more frequently than switching from compartment A. c Compartment switching was not associated with gene expression changes. The log2 fold change of differentially expressed genes (5-μm vs 14-μm pores) did not correlate with compartment or switching status. d TADs identified in migration with constriction were considered conserved if they overlapped < 80% with TADs identified in migration without constriction. Conserved TADs were more likely to be found in compartment A than non-conserved TADs.

Back to article page