Table 2 Mutations of drug-resistant genes in Beijing/W clinical strains carrying 9 m
From: A deletion in the RD105 region confers resistance to multiple drugs in Mycobacterium tuberculosis
Strains | SM | RFP | INH | EMB | OFL | AMK | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MIC (μg/mL) | Gene | MIC (μg/mL) | Gene | MIC (μg/mL) | Gene | MIC (μg/mL) | Gene | MIC (μg/mL) | Gene | MIC (μg/mL) | Gene | |||
rpsL | rrs1 | rpoB | katG | inhA | embB | gyrA | rrs2 | |||||||
1 | 16 | – | – | > 32 | 1 | S315 T AGC/ACC | – | 4 | – | 16 | D94G GAC/GGC | 0.5 | – | |
2 | 32 | – | A514C | > 32 | S531 L TCG/TGG | 8 | – | – | 8 | M306I ATG/ATC | 32 | D94N GAC/AAC | 1 | – |
3 | 16 | – | – | > 32 | S531 L TCG/TGG | 2 | S315 T AGC/ACC | – | 4 | – | 1 | – | 2 | – |
4 | 4 | – | C513T | 4 | D516V GAC/GTC | 2 | S315 T AGC/ACC | I21V ATC/GTC | 1 | – | 2 | D94G GAC/GGC | 2 | – |
5 | 4 | – | C513T | 8 | D516V GAC/GTC | 4 | S315 T AGC/ACC | – | 0.5 | – | 2 | – | 0.5 | – |
6 | > 32 | – | A514C | > 32 | S531 L TCG/TGG | 8 | S315 T AGC/ACC | – | 4 | – | 0.25 | – | 0.5 | – |
7 | 4 | – | C513T | 8 | D516V GAC/GTC | 4 | S315 T AGC/ACC | – | 1 | – | 0.25 | – | 1 | – |
8 | 4 | – | C513T | 4 | D516V GAC/GTC | 2 | S315 T AGC/ACC | – | 0.5 | – | 0.25 | – | 2 | – |
9 | 16 | – | – | > 32 | S531 L TCG/TGG | 1 | S315 T AGC/ACC | C-15 T | 4 | – | 16 | D94G GAC/GGC | 2 | – |