Fig. 5

Cluster analysis indicates genes involved in regenerative functions. a The heatmap depicts log fold change values for genes (rows) in anterior (ANT) and posterior (POST) regenerating fragments compared with sibling uncut control (CONT) larvae over the sampled regeneration time points (columns; 3 h post-bisection [hpb], 3 days post-bisection [dpb], and 6 dpb). Green indicates a positive fold change (upregulated with respect to uncut controls), whereas purple indicates a negative fold change (downregulated with respect to control). b Gene ontology (GO) term enrichments for each of the five clusters. The enrichment of each GO term is indicated by a circle where the area corresponds to the fraction of genes annotated with that term are present in the cluster, and the color of the circle corresponds to the corrected hypergeometric p value of term enrichment. Terms marked with an asterisk [*] are from the annotation set generated by mouse gene ortholog prediction (Fig. 5, Additional file 1: Figure S3)