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Table 3 Genes encoding FeS cluster proteins and FeS cluster biosynthesis proteins that are differentially regulated in OXY and NAO Spironucleus cells

From: Oxygen induces the expression of invasion and stress response genes in the anaerobic salmon parasite Spironucleus salmonicida

Protein name Abbr. In Fig. 2, 3 FeS cluster type OrthoMCL group Spironucleus salmonicida Giardia intestinalis WB Giardia intestinalis GS
Gene ID (SS50377_) NCBI accession OXY LFCa NAO LFCa Gene ID (GL50803_) LFCb Gene ID (GL50581_) LFCb
Fe-S cluster biosynthesis
 Cysteine desulfurase ISCS c OG5_126959 15482 EST44485.1 4.0 2.4 14519 - 3589 -
 Frataxin YFH1 c OG5_128372 10981 EST48875.1 1.5 - n/a n/a n/a n/a
 FeS cluster scaffold protein ISCU c OG5_127020 11862 EST48017.1 3.2 1.5 15196 - 3674 -
 NifU-like protein NFU1 c OG5_127523 19167 EST41448.1 4.0 1.1 32838 - 1173 -
 FeS cluster assembly factor NAR1 c OG5_196623 10213 EST49464.1 - - 33030 - 2775 -
 Cytosolic FeSprotein assembly CIA1 c OG5_127906 19091 EST41375.1 1.6 - 17550 - 1833 -
 Nucleotide-binding protein NBP35 c OG5_126620 15262 EST44817.1 3.1 - 10969 - 2003 -
Fe-S cluster proteins
 Diphthamide biosynthesis protein - 4Fe-4S OG5_127598 12464 EST47479.1 1.7 - 4248 - 3444 -
 DNA polymerase - 4Fe-4S OG5_128651 13679 EST46293.1 - 1.4 n/a n/a n/a n/a
 DNA repair helicase - 4Fe-4S OG5_127294 13430 EST46627.1 1.3 1.5 5631 - 3240 -
 DNA repair helicase RAD3 - 4Fe-4S OG5_127585 10417 EST49200.1 1.3 1.4 4328 - 2184 -
 DNA polymerase alpha - 4Fe-4S OG5_127945 14337 EST45766.1 - 1.3 6980 - 4344 -
 RNA polymerase RPB3 - 4Fe-4S OG5_127622 14437 EST45591.1 - - 1.1 7474 - 2249 -
 RNA polymerases I and III - 4Fe-4S OG5_128425 19186 EST41464.1 - - 1.9 10840 - 1230 - 0.8
 Cysteine-rich protein - 4Fe-4S OG5_159029 16132 EST44066.1 - - 1.5 10329 - 4058 -
 Ferredoxin Fd3 - 4Fe-4S OG5_159029 13915 EST45936.1 1.4 1.0 10329 - 4058 -
 Ferredoxin - 4Fe-4S OG5_136509 17123 EST43182.1 - 2.2 - 1.3 n/a n/a n/a n/a
 Glutamate synthase - 4Fe-4S OG5_126892 19044 EST41331.1 - 1.5 7195 - 3819 -
 Putative ferredoxin - 4Fe-4S OG5_126892 17234 EST43076.1 - - 1.1 7195 - 3819 -
 Putative ferrodoxin - 4Fe-4S OG5_187401 10151 EST49544.1 - 2.1 - 2.0 n/a n/a n/a n/a
 Radical SAM superfamily protein - 4Fe-4S OG5_138560 12417 EST47432.1 2.3 - 16519 - 358 0.7
 Histone acetyltransferase Elp3 - 4Fe-4S OG5_127324 10392 EST49177.1 2.9 2.5 16639 - 2520 -
 Glycerol-3-phosphate dehydrogenase - 2Fe-2S OG5_127956 15333 EST44764.1 - 1.1 16125 - 2252 -
 Molybdenum cofactor sulfurase - 2Fe-2S OG5_129340 18322 EST42015.1 1.7 1.6 14200 - 2926 -
 Selenophosphate synthase SPS-NifS ? OG5_131755 16780 EST43726.1 1.5 1.6 n/a n/a n/a n/a
 hypothetical protein - ? EIN_200440 18400 EST42092.1 - 1.9 n/a n/a n/a n/a
  1. a|Log2 (fold change)| > 1.0 with q-values < 0.05 from this study; '-' indicates not significant changes
  2. b|Log2 (fold change)| > 0.7 with p-values < 0.05 from Ma'ayeh et al. [25]; '-' indicates not significant changes
  3. ctransiently binds Fe-S clusters
  4. n/a indicates that the gene was not found in Giardia intestinalis