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Fig. 1 | BMC Biology

Fig. 1

From: RNA processing errors triggered by cadmium and integrator complex disruption are signals for environmental stress

Fig. 1

The numr-1 gene encodes an SR-like protein that influences RNA splicing. a NUMR-1 resembles an SR-like protein with an N-terminal RNA recognition-like motif, serine- and arginine-rich regions, and a C-terminal histidine-glycine-rich region [22,23,24]. b Clustered heat map of log2 gene expression changes caused by 300 μM cadmium relative to no cadmium, numr-1/2(RNAi) relative to control(RNAi) on agar without cadmium, or numr-1/2(RNAi) relative to control(RNAi) on agar with 300 μM cadmium. Correlation coefficients relative to the first column of data are shown below. A list by gene is provided in Additional file 2: Table S1. c Summary of alternative splicing events caused by numr-1/2(RNAi) relative to control(RNAi). A list by gene is provided in Additional file 4: Table S3. Percentage of events that were significantly changed are provided in parentheses. d RNA to DNA ratios of worms fed with control(RNAi) or numr-1/2(RNAi). e Enriched categories within genes alternatively spliced by numr-1/2(RNAi)

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