Fig. 4

Distribution of PRC1 (RING1B) and PRC2 (EZH2) over the HoxD cluster and regulatory landscapes in limb bud cells. a EZH2 and RING1B ChIP profiles in proximal (top two panels) and distal (bottom two panels) E12.5 limb bud cells. The CpG distribution is shown as green bars on top of the gene diagram. The red asterisk indicates an artifactual signal. b Magnification of the HoxD cluster showing the distribution of EZH2 and RING1B in proximal and distal limb cells. H3K27me3 ChIP tracks are shown for each tissue. The CpG islands are shown as green bars, and the CTCF and their orientations are depicted as blue (reverse strand) or red (forward strand) arrowheads