Fig. 4

Characteristics of four gene sets with distinct chromatin states. Genes with active promoters (TssA; n = 13,981), genes with poised enhancers but not active promoters (EnhPois; n = 4197), genes with flanking bivalent TSS/enhance but not active promoters (BivFlnk; n = 2452), and genes with repressive Polycomb but not active promoters (ReprPC; n = 4126). a, b Comparisons of expression and CG percentages among the four gene sets, respectively. c The dn/ds ratio comparison for the four gene sets corresponding to human-cattle orthologous genes. The statistical significances for comparisons were calculated using t test, where “***” means P < 0.001. d The expression (median of log₂ (FPKM+ 1)) for the four gene sets across 88 somatic tissues and cell types in cattle