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Fig. 3. | BMC Biology

Fig. 3.

From: Spatiotemporal mapping of RNA editing in the developing mouse brain using in situ sequencing reveals regional and cell-type-specific regulation

Fig. 3.

Regional editing. a Bubble charts of the editing level (derived from data in Additional files 789, and 10) for the investigated editing sites, by developmental stage, for the regions thalamus (T), neocortex (N), hippocampus (Hi), and hypothalamus (Hy). The color of the bubble indicates the average level of editing and the size of the bubble the average level of expression (log2 of the number of reads) within that particular region. Lines connecting bubbles indicate regions where the editing levels differ based on statistical testing with Kruskal-Wallis and post hoc Dunn-Sidak. The level of significance is presented in Additional file 9. b Bubble charts of the editing ratio (regional editing level for an editing site over the editing level of that editing site for the whole brain with the region excluded) for the investigated edited sites, by developmental stage, where the color indicates if the regional editing level is elevated (red), similar (white) to or lower than (cyan) the outside area. The stronger the color, the larger the deviation in editing level. The level of difference (Dunn pairwise testing with correction for multiple testing) between the regions are indicated as *p < 0.05, **p < 0.01, and ***p < 0.001 at the top of the charts and also presented in Additional file 8: Table S6. NA values (due to low read count) in gray. c The spatiotemporal editing level for Caps1 E/G, Gabra3 I/M, Kcna1 I/V, and Tmem63b Q/R, editing sites which display regionally different editing levels. As a reference, Blcap Y/C shows no regional deviations in the editing level. Data points are missing for neocortex and hippocampus in E15, as these regions could not be outlined at this stage of development. Other missing data points have been excluded due to low read count

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