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Fig. 3 | BMC Biology

Fig. 3

From: Mapping DNA interaction landscapes in psoriasis susceptibility loci highlights KLF4 as a target gene in 9q31

Fig. 3

Examples of CHi-C interactions adding complexity to a locus. Interactions are shown in the 6p22.3 (CDKAL1) locus (a) and the 1q21.3 (LCE3B, LCE3C) locus (b). The tracks include psoriasis (Ps) LD blocks as defined by SNPs in r2 > 0.8 with the index SNP, baited HindIII fragments, RefSeq genes (NCBI), H3K27ac and H3K4me3 P value signal in NHEK (ENCODE) and CD8+ primary naive T cells (Roadmap Epigenomics), TADs (shown as bars) and CHi-C interactions significant at CHiCAGO score ≥ 5 (shown as arcs) in three conditions: unstimulated HaCat cells (purple), HaCaT cells stimulated with IFN-γ (red) and My-La cells (blue). The highlighted region indicates the psoriasis LD block. The figure was made with the WashU Epigenome Browser, GRCh37/hg19 [31]

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BMC Biology

ISSN: 1741-7007

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