Fig. 2
Reduced lymphocytes in the GALT of β7-F185A KI mice. Representative histological sections of the small intestine (SI) (a), colon (b), and Peyer’s patch (PP) (c) of WT, β7-F185A KI (KI), and β7-KO (KO) mice were analyzed by hematoxylin and eosin staining. Scale bars, 100 μm. d Quantification of the average diameter of PP in the individual group of mice (n = 9 per group). ***P < 0.001 (Student’s t test). e Flow cytometry enumeration of lymphocyte distribution in lymphoid organs from the individual group of mice (n = 9 per group). PB, peripheral blood; PLN, peripheral lymph node; MLN, mesenteric lymph node; BM, bone marrow; IEL, intraepithelial lymphocyte; LPL, lamina propria lymphocyte. Results are presented as cell number × 106, AP < 0.01; AAP < 0.005 (Student’s t test). BThe cecum was excluded. ND, not detected. Data are mean ± s.d. of at least 3 independent experiments (d, e)