Fig. 7

Potential effect of HHV-7 infection on human gene expression in the stomach. a Association of the human gene expression pattern with HHV-7 infection in the stomach. Stomach samples (n = 203) were classified into the two clusters based on the 1000 most highly expressed human genes. (Top) The relative expression levels of human genes are shown as a heatmap. (Middle) Distribution of the samples positive for HHV-7 (n = 78). Note that HHV-7-positive samples accumulated in cluster 1. (Bottom) Deconvolution analysis of human leukocytes residing in the stomach. The proportions of the respective human leukocytes are shown as a heatmap. b GO enrichment analysis of the DEGs between clusters 1 and 2. The top 10 terms significantly upregulated (top) and downregulated (bottom) in cluster 1 compared to those in cluster 2 are shown. c Differential expression of the genes associated with the digestion process. The expression levels of 11 genes associated with the digestion process (CAPN8, CAPN9, CCKAR, CCKBR, PGA3-5, SST, SSTR1, TFF1, and TFF2) in clusters 1 and 2 are shown as TPM