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Fig. 2 | BMC Biology

Fig. 2

From: TDP-43 prevents retrotransposon activation in the Drosophila motor system through regulation of Dicer-2 activity

Fig. 2

Pharmacological and genetic suppression of RTEs revert TBPH mutant phenotypes. a Number of peristaltic waves of Ctrl (w1118) and Δtb (tbphΔ23/tbphΔ23) fed with NRTI drugs (D) compared to vehicle only (V). n = 20. b Number of peristaltic waves of Ctrl (w1118) and Δtb (tbphΔ23/tbphΔ23) fed with NNRTI drugs (D) compared to vehicle only (V). n = 20. c Number of peristaltic waves of Ctrl (w1118), Δtb-GFP-IR (tbphΔ23,elav-GAL4/tbphΔ23; UAS-GFP-IR/+), Δtb-gypsy-IR3 (tbphΔ23,elav-GAL4/tbphΔ23; UAS-gypsy-IR3/+), and Δtb-gypsy-IR4 (tbphΔ23,elav-GAL4/tbphΔ23; UAS-gypsy-IR4/+). n = 20. d Confocal images of third instar NMJ terminals in muscle 6/7 second segment stained with anti-HRP (in green) in Ctrl, Δtb-GFP-IR, and Δtb-gypsy-IR3. e Quantification of branch number. n = 15. f Confocal images of third instar NMJ terminals in muscle 6/7 second segment stained with anti-HRP (in green) and anti-GluRIIA (in magenta) in Ctrl, Δtb-GFP-IR, and Δtb-gypsy-IR3. g Quantification of GluRIIA intensity. n > 200 boutons. *p < 0.05, **p < 0.01, ***p < 0.001 calculated by one-way ANOVA, error bars SEM. Scale bar 10 μm (d) and 5 μm (f)

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