Fig. 4

Soluble high fibre causes increased growth delay in irradiated bladder cancer cell xenografts, and responses are influenced by gut microbiota composition. a Tumour growth in RT112 flank xenografts irradiated with 6 Gy IR, in mice fed low-fibre, high mixed fibre, high insoluble fibre, and high soluble fibre diets (n = 8 for each group). Tumour curve slopes were calculated by linear regression to represent tumour growth rates and compared by ANOVA. b The Kaplan-Meier survival curves for mice showing plots of time to treble tumour volume. c Mice in the soluble HF group were stratified into responders and non-responders based on tumour radiation response. d Shannon’s index of gut microbiota in responders and non-responders by the Kruskal-Wallis test. Error bars represent the interquartile range of diversity scores. e Principal coordinate analysis of gut samples (n = 8) in the soluble HF group by response using the Bray-Curtis dissimilarity