Fig. 1.

Influence of the protein length and of the mutated residues’ RSA (in %) on the mutational robustness, evaluated from the ΔΔG values (in kcal/mol) of μSBSs from the sets \({\mathcal {M}_{\text {PoP}}}\) (a,c,e-h) and \({\mathcal {M}_{\text {Exp}}}\) (b,d). a, b ΔΔG distribution for different RSA ranges. c, d Mean ΔΔG per RSA bin as a function of the RSA; the chosen bin width is equal to 1%. e Mean ΔΔG per protein as a function of the protein length for all residues and f for surface residues (RSA >20%). g Mean ΔΔG per protein as a function of protein length (blue points) and protein core to length ratio, defined as the number of residues in the core over the number of residues in the protein (orange points). h Difference between the mean ΔΔG per RSA bin of long proteins (L>200 residues) and short proteins (L≤200 residues) as a function of RSA