Table 1 Comparison between mutational robustness and fitness: computed fraction of destabilizing, neutral, and stabilizing μSBSs from \(\mathcal {M}_{\text {PoP}}\) and experimentally characterized fraction of deleterious, neutral, and advantageous mutations. The fitness thresholds for defining the mutation phenotypes are chosen by the authors for mutations in [55]; for the other sets of experimental mutations: deleterious if the fitness is lower than the mean of loss-of-function and wild-type scores, neutral if the fitness is between that threshold and 1.25 times the wild-type score, and advantageous otherwise
