Table 2 Mean ΔΔG (in kcal/mol) of all μSBSs in \(\mathcal {M}_{\text {PoP}}\) as a function of the BLOSUM62 class. Positive BLOSUM scores indicate more likely amino acid substitutions and negative scores, less likely substitutions. The fraction of stabilizing (Stab), neutral (Neut), and destabilizing (Dest) substitutions in each class is also reported

From: Large-scale in silico mutagenesis experiments reveal optimization of genetic code and codon usage for protein mutational robustness