Table 3 Comparison between the mean ΔΔG values (in kcal/mol) of single and multiple nucleotide substitutions (μSBS and μMBS) in \(\mathcal {M}_{\text {PoP}}\) and the fraction of stabilizing, neutral and destabilizing mutations. Core residues have an RSA ≤20% and surface residues an RSA >20%

From: Large-scale in silico mutagenesis experiments reveal optimization of genetic code and codon usage for protein mutational robustness