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Table 6 Mean ΔΔG (in kcal/mol) for μSBSs from \(\mathcal {M}_{\text {PoP}}\) obtained from transitions and transversions. In the upper part of the table, the mean ΔΔG includes the synonymous mutations (with ΔΔG=0), while the lower part is without them

From: Large-scale in silico mutagenesis experiments reveal optimization of genetic code and codon usage for protein mutational robustness

Mutation

〈ΔΔG〉

Stab (%)

Neut (%)

Dest (%)

With synonymous mutations

Transitions

0.51

2

63

35

Transversions

0.60

4

53

43

Without synonymous mutations

Transitions

0.79

3

44

53

Transversions

0.73

5

43

52