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Table 2 Examples of highly differentiated PGx variants. This table lists some examples of highly diverged PGx variants in the three SIRE groups under consideration. In the table, “Ref. Pop.” refers to reference population, OR refers to odds ratios, and ARI refers to the absolute risk increase percentage. Values in brackets specify the 95% confidence intervals for each computation

From: Population structure and pharmacogenomic risk stratification in the United States

    Effect allele frequency     
rsID Drug Effect White Black Hispanic Ref. Pop. OR ARI Accuracy
rs1045642 Fentanyl Dosage 0.78 0.37 0.70 White 3.26 (2.96, 3.60) 26.1 (24, 28) 68.5 (67.0, 69.9)
rs9934438 Warfarin Dosage 0.38 0.83 0.33 Black 8.27 (7.18, 9.54) 45.93 (44, 48) 66.53 (65.03, 68.03)
rs2884737 Warfarin Dosage 0.27 0.04 0.18 Black 8.99 (7.43, 10.87) 36.0 (34, 38) 52.5 (50.5, 54.5)
rs2500535 Nortriptyline Efficacy 0.05 0.06 0.26 Hispanic 6.1 (5.40, 6.82) 20.3 (18, 22) 85.2 (84.6, 85.9)
rs11615 Platinum compounds Efficacy 0.37 0.88 0.64 Black 9.90 (8.85, 11.09) 45.95 (45, 47) 63.5 (62.4, 64.6)
rs20455 Atorvastatin Efficacy 0.36 0.79 0.40 Black 14.2 (11.11, 18.17) 35.71 (34, 37) 50.01 (47.9, 52.1)
rs1048943 Capecitabine, docetaxel Efficacy 0.04 0.02 0.27 Hispanic 12.74 (11.14, 14.79) 39.4 (37, 42) 87.3 (86.5, 88.1)
rs4646450 Tacrolimus Metabolism 0.16 0.84 0.33 Black 66.80 (49.17, 90.88) 63.15 (62, 65) 71.5 (70.2, 7.2)
rs6977820 Antipsychotics Toxicity 0.04 0.28 0.05 Black 14.8 (12.13, 18.14) 45.96 (44, 48) 60.09 (58.4, 6.1)
rs1801394 Methotrexate Toxicity 0.46 0.72 0.67 White 2.82 (2.63, 3.02) 24.68 (23, 26) 59.40 (58.2, 60.1)
rs16969968 Nicotine Toxicity 0.66 0.95 0.80 Black 8.17 (6.97, 9.59) 26.6 (26, 28) 43.17 (41.4, 44.9)