Table 2 Examples of highly differentiated PGx variants. This table lists some examples of highly diverged PGx variants in the three SIRE groups under consideration. In the table, “Ref. Pop.” refers to reference population, OR refers to odds ratios, and ARI refers to the absolute risk increase percentage. Values in brackets specify the 95% confidence intervals for each computation
From: Population structure and pharmacogenomic risk stratification in the United States
Effect allele frequency | |||||||||
|---|---|---|---|---|---|---|---|---|---|
rsID | Drug | Effect | White | Black | Hispanic | Ref. Pop. | OR | ARI | Accuracy |
rs1045642 | Fentanyl | Dosage | 0.78 | 0.37 | 0.70 | White | 3.26 (2.96, 3.60) | 26.1 (24, 28) | 68.5 (67.0, 69.9) |
rs9934438 | Warfarin | Dosage | 0.38 | 0.83 | 0.33 | Black | 8.27 (7.18, 9.54) | 45.93 (44, 48) | 66.53 (65.03, 68.03) |
rs2884737 | Warfarin | Dosage | 0.27 | 0.04 | 0.18 | Black | 8.99 (7.43, 10.87) | 36.0 (34, 38) | 52.5 (50.5, 54.5) |
rs2500535 | Nortriptyline | Efficacy | 0.05 | 0.06 | 0.26 | Hispanic | 6.1 (5.40, 6.82) | 20.3 (18, 22) | 85.2 (84.6, 85.9) |
rs11615 | Platinum compounds | Efficacy | 0.37 | 0.88 | 0.64 | Black | 9.90 (8.85, 11.09) | 45.95 (45, 47) | 63.5 (62.4, 64.6) |
rs20455 | Atorvastatin | Efficacy | 0.36 | 0.79 | 0.40 | Black | 14.2 (11.11, 18.17) | 35.71 (34, 37) | 50.01 (47.9, 52.1) |
rs1048943 | Capecitabine, docetaxel | Efficacy | 0.04 | 0.02 | 0.27 | Hispanic | 12.74 (11.14, 14.79) | 39.4 (37, 42) | 87.3 (86.5, 88.1) |
rs4646450 | Tacrolimus | Metabolism | 0.16 | 0.84 | 0.33 | Black | 66.80 (49.17, 90.88) | 63.15 (62, 65) | 71.5 (70.2, 7.2) |
rs6977820 | Antipsychotics | Toxicity | 0.04 | 0.28 | 0.05 | Black | 14.8 (12.13, 18.14) | 45.96 (44, 48) | 60.09 (58.4, 6.1) |
rs1801394 | Methotrexate | Toxicity | 0.46 | 0.72 | 0.67 | White | 2.82 (2.63, 3.02) | 24.68 (23, 26) | 59.40 (58.2, 60.1) |
rs16969968 | Nicotine | Toxicity | 0.66 | 0.95 | 0.80 | Black | 8.17 (6.97, 9.59) | 26.6 (26, 28) | 43.17 (41.4, 44.9) |