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Fig. 5 | BMC Biology

Fig. 5

From: Hyperactivated Wnt-β-catenin signaling in the absence of sFRP1 and sFRP5 disrupts trophoblast differentiation through repression of Ascl2

Fig. 5

Hyperactivation of canonical Wnt signaling disturbs EPC trophoblast differentiation via repressing Ascl2 expression. a Volcano plot displaying differentially expressed genes (DEG) between the Cyp19-cre and Cyp19-cre; Ctnnb1f(EX3)/+ placentas (fold change > 1.5, P value < 0.05). b, c GO enrichment analysis of increased genes (b) and decreased genes (c) between Cyp 19-cre and Cyp19-cre; Ctnnb1f(EX3)/+ placentas. d Heatmap showing the expression of trophoblast-located genes in the Cyp19-cre and Cyp19-cre; Ctnnb1f(EX3)/+ placentas. e, f The expression of Wnt target genes and Ascl2 was confirmed by qRT-PCR. Values are normalized by Gapdh expression level and indicated as means ± SD. N = 3. *P < 0.05

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