Fig. 7From: TRIM25 promotes Capicua degradation independently of ERK in the absence of ATXN1LThe proposed mechanistic model of the CIC-ATXN1L-TRIM25 interaction. a CIC-ATXN1L form a repressive complex which stabilizes CIC from degradation by TRIM25. b In the absence of ATXN1L, CIC is targeted by TRIM25 for degradation by ubiquitination and transported for degradationBack to article page