Fig. 6

Copy number variation is correlated with evolutionary rate and expression levels. a The distribution of coefficient of variation (CV) in copy number for each gene using population genomics data from four strains. The top and bottom 25% of genes in terms of CV (labeled in gray) are categorized into non-conserved and conserved copy number (CN) groups, respectively. b Pairwise Ka/Ks values are significantly lower in the conserved CN group and higher in the non-conserved CN group when compared to those of the whole genome. c Gene expression of the non-conserved CN group is significantly lower than that of the conserved CN group. ***p value < 0.0001, two-tailed Mann-Whitney U test