Fig. 2

Composition of A. godoyi ETC complex I (CI). The figure lists the 44 CI subunits that have been identified in mammalian CI (see Table 1 and [46]), plus two γ carbonic anhydrase (γCA) subunits (dashed green oval) that are not present in mammalian or fungal CI, but are CI components in plants [53] and protists [54]. The blue-shaded oval encompasses the 17 subunits that comprise alphaproteobacterial (Paracoccus denitrificans) CI [52]. The smaller gray-shaded oval lists the 14 subunits that define the minimal active CI, with those subunits encoded in A. godoyi mtDNA highlighted in the yellow rectangle. Outside of the blue-shaded oval are listed 27 supernumerary, eukaryote-specific CI subunits, with those underlined considered by Brandt [44] to be metazoan-specific. With five exceptions (shown with strikethrough), all of these supernumerary subunits are present in A. godoyi, as well as the fungal-specific subunits NUUM and NUXM (dashed violet oval)