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Fig. 5 | BMC Biology

Fig. 5

From: Modeling confinement and reversibility of threshold-dependent gene drive systems in spatially-explicit Aedes aegypti populations

Fig. 5

Sensitivity of model outcomes for replacement, remediation, and confinement of translocations. Changes are depicted in the proportion of 50 stochastic simulations that result in fixation for replacement, remediation, and confinement of translocations. Proportions are compared to those in the first row of Fig. 4 as we vary (i) the mean dispersal distance of adult mosquitoes (± 50%), (ii) the duration of the larval life stage (± 2 days), (iii) the baseline adult mortality rate (± 2%), and (iv) the fitness cost associated with being homozygous for the translocation (+ 10% or + 20%). Fitness costs have the greatest impact on the release scheme required for the system to be fixed or remediated from the population, given the life parameters considered. Fitness costs also lead to more batch migration events being required for invasion of Trinity Park. A small increase in the baseline adult mortality rate leads to slightly fewer batch migration events being required for invasion of Trinity Park; however, comparison to migration rates inferred from field data suggests that confinement is still expected

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