Fig. 3

TADE drive. a In the TADE drive, germline activity disrupts the target gene, and the nuclease promoter is selected to minimize embryo activity. The target gene is assumed to be haplolethal, so any individuals inheriting one disrupted target allele will be nonviable, even if the other allele is drive or wild-type. b The speed at which a TADE drive is expected to reach 99% of individuals in the population with varying introduction frequency and drive fitness. The dashed line indicates the introduction frequency threshold in the deterministic model. c Same as b, but with varying germline and embryo cleavage rate