Fig. 9
From: Performance analysis of novel toxin-antidote CRISPR gene drive systems
Resistance to TA systems. Analysis was conducted for drive systems with 100% cleavage rates (germline only for TADE) and 95% drive homozygote fitness. Each cleavage event was assumed to result in a functional r1 allele instead of a disrupted target allele with 10% probability. The number of gRNAs was varied, and a resistance allele was considered to be a “complete” r1 allele only if all gRNA cleavage sites possessed r1 sequences. The vertical axis shows the frequency of complete r1 alleles after 100 generations