Fig. 3

RA-associated chromatin dysregulation is positively correlated with the serum CRP levels of RA patients. a, b Linear regression analysis was used to compare RAAS with DAS28-CRP score (a) and with CRP serum concentration (b). The shading represents the confidence interval. The solid line was fit from linear regression, and the p value and the square of the coefficient of correlation (R²) were calculated using the “OLS” function in the statsmodels package in Python. P < 0.05 were considered significant. c Barplot showing the average serum CRP levels in OA and RA patients. The values of p were calculated with an unpaired t-test. **p < 0.01. Error bar represent standard error of the mean (SEM). d Venn diagrams showing the numbers and p for overlap between the regulation of OC differentiation gene set or the proinflammatory gene set and C3-related genes (identified by GREAT). P was calculated using Fisher’ exact test, ****p < 0.0001. e Normalized ATAC-seq profiles at the TNFRSF11A and IL-6 loci in OA and RA patients. Shaded regions are more accessible representative peaks in RA. OC, osteoclast; OA, osteoarthritis; RA, rheumatoid arthritis; C3, cluster 3; DAS28-CRP: disease activity score DAS28 based on C-reaction protein levels; RAAS, RA-associated ATAC-seq score