Fig. 4.
Regenerative capacity. a Scatter plot showing the regenerative capacity for all N=7 organisms generated with a fixed gene regulation matrix GR using different matrices CD, A, and SG (for cell division, cellular adjacency, and signal transduction, respectively). Each point represents an organism. The x-axis is the fraction of all cell types that are pluripotent (fg). The y-axis is the fraction of cell types in the organism that are adult pluripotent cells (fp). Noise has been added to the position of points to make their density more apparent. Colors of points indicate the topology of their lineage graphs (as in Fig. 2): unicellular: dark gray; cyclic: light gray; chain: red; tree: black; DAG: blue. Points above the gray band are regenerative organisms (with fp/fg>1). A total of 13,177 graphs were used to generate this plot (see also Additional file 1: Figure S12). b Box plot of proportion of regenerative graphs of different topologies across all organisms in the data (see also Additional file 1: Figure S13a). For each GR used in our data, for a given graph topology, we looked at the fraction of graphs with regenerative capacity >1 (equivalent to the fraction of points of a certain color that occur above the gray band in a). Boxes represent quartiles of the data set. Lines inside the box show the median, while whiskers show the rest of the distribution. Outliers are shown as diamonds. A total of 4,852,994 graphs were used to generate this plot