Fig. 6
From: The Wnt-specific astacin proteinase HAS-7 restricts head organizer formation in Hydra
Structural homology model of the putative HyWnt3:HAS-7 complex. a Overview of HAS-7 (surface potential) complexed with HyWnt3 (yellow cartoon presentation). The active site Zn-ion of the astacin is shown as pink sphere. b Detailed view inside the active site pocket, shown in standard orientation with the Zn-ion located at the bottom of the cleft. c Alignment of amino acid sequences in different Hydra Wnt proteins encompassing the putative DP cleavage motif in HyWnt3. NvWnt3, Nematostella vectensis Wnt3; mWnt3, mouse Wnt3; XWnt8, Xenopus Wnt8