Fig. 5
From: Divergent camptothecin biosynthetic pathway in Ophiorrhiza pumila
In vivo labelling to study the biosynthesis of O. pumila apical cuttings by feeding with deuterated metabolites. a, b Selected deuterium intermediates in the CPT biosynthesis pathway and their chemoenzymatic synthesis. c O. pumila apical cuttings were given the deuterated metabolites d4-strictosidine and d4-strictosidinic acid as feeding precursors. d Labelled poststrictosidine metabolite products with pentacyclic pyrroloquinoline scaffolds detected by in vivo feeding experiments