Fig. 3

Assessment of genomic integrity in immortalized placental cell lines. a Manhattan plot of whole genome CNVs organized by chromosome; copy number gains (red), copy number losses (blue) show the presence of CNV in most of the placental cell lines but not in the fibroblasts used for comparison. b Box plots depicting proportion of Chr Y mapped reads normalized to a known male sample, iRFb-XY; cell lines were identified as male if mean > 0.5 (blue), or as female if mean < 0.5 (pink). c Representative metaphase spreads (n=20); 10uM scale bar. d Box plots of chromosome count results; median ± standard deviation values included above each plot