Fig. 3

Antiviral efficacy assessment. a List of the drugs and compounds with their corresponding mechanism of action (MoA) and doses used in this work. b Percentage of survival (red) and percentage of infected cells (blue) normalized to DMSO (infected) control. Coloured intervals indicate the standard deviation of two biological replicates. Two-way ANOVA was performed to assess the statistical significance of each condition (*p<0.05, **p<0.005, ***p<0.0005). c Distribution of intensity of the coronavirus anti-NP signal at single-cell level for each tested compound. One-way ANOVA on the means of two biological replicates was performed to assess the statistical significance of each condition (*p<0.05, **p<0.005, ***p<0.0005). d Representative images of MRC-5 cells non-infected, or infected with CoV-229E. Hoechst staining for nuclei is visualized in blue, and anti-coronavirus nucleoprotein antibody against CoV-229E in yellow