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Table 1 Cell division defects found in SRCAP depleted HeLa cells

From: The ATPase SRCAP is associated with the mitotic apparatus, uncovering novel molecular aspects of Floating-Harbor syndrome

  

Control

RNAi

  

Mock (%)

Scramble (%)

SRCAP A (%)

SRCAP B (%)

Metaphase

MS

4.38 ± 2.58

0

6.21 ± 4.43

***(scramble)

0

CM

15.31 ± 14.45

3.30 ± 5.80

57.36 ± 16.78***

47.90 ± 5.90***

ASM

2.25 ± 0.45

0

29.93 ± 2.80***

20.8 ± 5.90***

Telophase

CB

6.00 ± 1.97

1.00 ± 1.70

8.45 ± 4.96

*(mock), ***(scramble)

38.20 ± 3.60***

LIB

1.87 ± 0.67

8.10 ± 1.10

28.69 ± 9.21**

23.80 ± 3.60***

MC

2.16 ± 0.49

1.90 ± 1.70

14.21 ± 3.74***

9.30 ± 2.30***

  1. CB, chromatin bridges; CM, chromosome misalignments; LIB, long intercellular bridges; MC, multinucleated cells; MS, multipolar Spindles
  2. The results are expressed as mean ± SD values from three independent replicate experiments: *P < 0.05; **P < 0.005; and ***P < 0.0005 compared with the controls group by Fisher’s exact test
  3. Notably, MS found in cells treated with SRCAP A are statistically significant (***) compared to scramble, but not to mock. CB show different statistically significant levels depending on comparison between SRCAP A and scramble (***) or mock (*)
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BMC Biology

ISSN: 1741-7007

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