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Table 1 Cell division defects found in SRCAP depleted HeLa cells

From: The ATPase SRCAP is associated with the mitotic apparatus, uncovering novel molecular aspects of Floating-Harbor syndrome

   Control RNAi
   Mock (%) Scramble (%) SRCAP A (%) SRCAP B (%)
Metaphase MS 4.38 ± 2.58 0 6.21 ± 4.43
***(scramble)
0
CM 15.31 ± 14.45 3.30 ± 5.80 57.36 ± 16.78*** 47.90 ± 5.90***
ASM 2.25 ± 0.45 0 29.93 ± 2.80*** 20.8 ± 5.90***
Telophase CB 6.00 ± 1.97 1.00 ± 1.70 8.45 ± 4.96
*(mock), ***(scramble)
38.20 ± 3.60***
LIB 1.87 ± 0.67 8.10 ± 1.10 28.69 ± 9.21** 23.80 ± 3.60***
MC 2.16 ± 0.49 1.90 ± 1.70 14.21 ± 3.74*** 9.30 ± 2.30***
  1. CB, chromatin bridges; CM, chromosome misalignments; LIB, long intercellular bridges; MC, multinucleated cells; MS, multipolar Spindles
  2. The results are expressed as mean ± SD values from three independent replicate experiments: *P < 0.05; **P < 0.005; and ***P < 0.0005 compared with the controls group by Fisher’s exact test
  3. Notably, MS found in cells treated with SRCAP A are statistically significant (***) compared to scramble, but not to mock. CB show different statistically significant levels depending on comparison between SRCAP A and scramble (***) or mock (*)