Fig. 2
From: The role of the odorant receptors in the formation of the sensory map
Local increase of cAMP and Ca2+ coupled to odorant receptors expressed at the cilia and at the axon terminal. Schematic diagram of the signaling pathway coupled to the odorant receptors (OR) expressed at the cilia and at the axon terminal of olfactory sensory neurons. Both the ORs expressed at the cilia and the ORs at the axon terminal are coupled to local increase of cAMP and Ca2+. At the cilia, the influx of Ca2+ through the CNG channels leads to the opening of Ca2+-dependent Cl- channels (not shown in figure). The presence of these Cl- channels also at the axon terminal remains elusive. AC III adenylyl cyclase III, CaM Calmodulin, PDE phosphodiesterase, PEBP1 phosphatidylethanolamine binding protein-1 indicated by blue dots, at the axon terminal, while odorant molecules are indicated by dots of different colors, at the cilia