Fig. 5

Network of metabolite interactions derived from WGCNA and the potential mechanism proposed from the targeted metabolomics. A WGCNA on the targeted metabolomics. The clustering dendrogram generated from the pairwise similarities of the metabolites resulted in 3 modules, gray, black, and cyan. The metabolite network is visualized by a heatmap that depicts the topological overlap matrix among all the metabolites, with yellow for dissimilarity and red for similarity. B The network nodes of the metabolite interactions derived from the black module of the WGCNA. The red nodes represent the PCs in the 17 features pattern. C A hypothetical model from the metabolomics indicators and the interaction network related to the PCs