Fig. 8
From: An HSP90 cochaperone Ids2 maintains the stability of mitochondrial DNA and ATP synthase
A proposed model of how the Hsc82-Ids2 chaperone complex regulates mtDNA and mitochondrial functions. Atp3 may be folded by the Hsc82-Ids2 chaperone complex before being imported into mitochondria. However, in ids2Δ cells, Atp3 may be degraded and incompletely assembled complex V may prevent protons from flowing across the IM. To overcome the stress of continuously increasing proton concentration in IMS, mitochondria may eliminate mtDNA to disrupt ETC and stop proton accumulation