Fig. 3.

Overview of the process by which tigecycline binds to Tet(X4). A Surface representation of the tigecycline (T1C) binding cavity. B Active site recognition of T1C by hydrogen-bonding of Tet(X4) (protein residues in green, T1C in orange, FAD in yellow, hydrogen bonds as black dashed lines). C Interaction between T1C and Tet(X4). Residues around the binding pocket are depicted as green sticks, T1C is depicted in orange, and FAD is depicted in yellow