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Table 1 Susceptibility of tetracyclines in E. coli BW25113 harboring a pBAD18 vector which contains the tet(X2), tet(X4), or mutated tet(X2) gene

From: Structural and mechanistic basis of the high catalytic activity of monooxygenase Tet(X4) on tigecycline

E. coli BW25113 strains

MIC (mg/L)

Tetracycline

Minocycline

Tigecycline

Vector control

2

2

0.25

29522

1

0.25

0.125

Tet(X2)

32

4

1

Tet(X4)

64

16

16

L282S

32

8

4

V329M

32

8

2

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BMC Biology

ISSN: 1741-7007

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