Fig. 3

Synteny analysis of the gasdermin E, pejvakin, and gasdermin A/B loci from different species. Schematic diagrams showing the conservation of synteny in the gsdme loci A, pjvk loci B, and gsdma/b loci C in Mammalia (Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus), Aves (Gallus gallus), Reptilia (Pediscus sinensis), Amphibia (Xenopus tropicalis), and fish (Osteychthyes: Latimeria chalumnae, Danio rerio, Tetraodon nigroviridis, and Chondrichthyes: Callorhinchus milii). In B, for Danio rerio, the synteny of the genes surrounding the mammalian pjvk is presented to illustrate that fish pjvk is not located in that part of the genome. In C, amphibian synteny of genes surrounding mammalian gsdma gene is shown to illustrate that no gsdma is present. Conserved genes are indicated in different colors and the direction of gasdermin gene transcription is indicated with arrows. The position of the centromeres is indicated with a blue dot. An asterisk denotes genes from the same family found in two of the genomic environments (gsdme/pjvk, gsdme/gsdma, or pjvk/gsdma); three asterisks denote genes from the same family found in the three genomic environments