Fig. 1

Evolution of cell-to-cell gene expression variability during the main pathways of normal hematopoietic differentiation (HBM1). Cell populations belonging to each differentiation pathway were first selected and then ordered according to the pseudotime calculated by Slingshot. The average intercellular entropy of all genes was then calculated on a sliding window of 50 cells which moves across the pseudotime with a step of 10 cells (the color of each point on the graph correspond to the nature of the first cell in the corresponding sliding window). A Erythropoiesis. B Granulopoiesis. C Dendritic differentiation. D B lymphopoiesis