Fig. 6
From: Fluid shear stress enhances T cell activation through Piezo1
Schematic of enhanced T cell activation by FSS and CD3/CD28 antibodies. FSS activates Piezo1, enabling calcium influx. The calcium influx increases ZAP70 phosphorylation, and activation of the transcription factors NFAT, NF-κB, and AP-1. This in turn leads to increased expression of cytokines such as IL-2