Fig. 1

Single-base methylomes in primary dermal fibroblasts of seven vertebrate species. a Phylogenetic relationships between the studied species. For each species, we indicate whether the genome contains an annotated DNMT1 (D1), DNMT3A (D3A), DNMT3B (D3B) and DNMT3L (D3L) gene. b Density plot of the distribution of CG ratios (CpG observed/expected) calculated in 0.5 kb genomic sliding windows. c Average methylation of CG (upper panel) and CH (lower panel) sites with at least 5 unique reads in WGBS datasets generated from dermal fibroblasts. d Metaplot of CG methylation levels over Ensembl genes and 10 kb flanking sequences calculated from the WGBS datasets in dermal fibroblasts. TSS: Transcription start site, TTS: Transcription termination site. e Violin plots of WGBS CG methylation levels in different genomic features in dermal fibroblasts. Median values are indicated by white circles