Fig. 5

Shuffled, noise-added, and simulated data show activity-connectivity relationship that is distinct from the brain data. A Schematic showing the generation and analysis of noise-added, shuffled, or simulated data. B–E Different datasets with neuronal activity time series (top), cell-wise correlation matrix (middle), and the graphed functional connectivity and activity relationship (bottom). B Original data of an example subject. C Different levels of noise were added to the original data, resulting in the loss of the activity-connectivity relationship observed in the original brain data. Note that the Y axis range is different across the panels. D Neuronal activity time series of the original data were shuffled in both space and time. The activity-connectivity relationship observed in the original brain data was lost. E A simulated dataset shows the activity-connectivity relationship that is distinct to the brain data and is also sensitive to the levels of noise. The number of replicates used is 9