Fig. 2

Comparison of the inter-chromosomal interactome across species. A Correlation between chromosome length variance and contact probability between each two chromosomes. B Differences in clustering coefficients among the three groups of species. C Average degree of difference among three groups of species. Two outlier samples (DF1 in chicken and AB.9 in zebrafish) with extremely low clustering coefficients were excluded in (B) and (C). D, E Correlation between genome size and two trans network parameters (left panel: clustering coefficient, defined as the degree to which the nodes in a network tended to cluster together; right panel: average degree, defined as the average number of neighbors per node) for 12 species (D) and 10 mammals (E). F Inter-species comparison of inter-chromosomal gene-gene contacts. The Spearman’s r between contact frequencies of 4,853 single-copy orthologous genes across 12 species. G Pearson’s r between the inter-species similarity of gene-gene interaction frequency and their divergence time. For (A–C), data are presented as mean ± SD. P values in (B) and (C) were calculated using two-sided Wilcoxon rank-sum test