Table 1 The number of genes, known deafness genes and highly variable genes in the high variant load lists at different minor allele frequencies and impacts

All

High

0.005

23

2 (adj.p=1)

3 (adj.p=1)

29

7 (adj.p=8.95 × 10⁻⁴)*

4 (adj.p=0.98)

All

High

0.01

28

2 (adj.p=1)

4 (adj.p=0.88)

54

9 (adj.p=0.0016)*

2 (adj.p=1)

All

High

0.05

135

6 (adj.p=1)

15 (adj.p=0.021)*

116

15 (adj.p= 1.60 × 10⁻⁵)*

10 (adj.p=0.82)

All

High

0.1

222

18 (adj.p=0.011)*

23 (adj.p= 0.0029)*

156

19 (adj.p= 2.38 × 10⁻⁵)*

12 (adj.p=1)

All

High

0.2

347

24 (adj.p=0.014)*

35 (adj.p= 9.35 × 10⁻⁵)*

231

21 (adj.p= 6.92 × 10⁻⁴)*

24 (adj.p=0.0020)*

All

High

1

635

32 (adj.p=0.29)

65 (adj.p= 3.32 × 10⁻⁹)*

630

39 (adj.p= 0.0031)*

72 (adj.p= 1.49 × 10⁻¹²)*

All

Low

0.1

61

5 (adj.p=1)

9 (adj.p=0.033)*

36

0 (adj.p=1)

8 (adj.p=0.0035)*

Male

High

0.1

181

17 (adj.p=7.67 × 10⁻⁴)*

15 (adj.p=0.099)

156

9 (adj.p=0.56)

8 (adj.p=1)

Female

High

0.1

184

15 (adj.p=0.0086)*

16 (adj.p=0.052)

158

20 (adj.p= 1.87 × 10⁻⁶)*

13 (adj.p=0.16)

All

High (MSC)

0.1

27

4 (adj.p=1)

7 (adj.p=1.88 × 10⁻⁴)*

11

4 (adj.p=0.21)

2 (adj.p=0.57)

Male

High (MSC

0.1

14

2 (adj.p=1)

5 (adj.p=6.12 × 10⁻⁴)*

18

4 (adj.p=1)

6 (adj.p=1.60 × 10⁻⁴)*

Female

High (MSC)

0.1

13

1 (adj.p=1)

2 (adj.p=0.77)

8

3 (adj.p=0.45)

3 (adj.p=0.020)*