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Table 1 The number of genes, known deafness genes and highly variable genes in the high variant load lists at different minor allele frequencies and impacts

From: Investigating the characteristics of genes and variants associated with self-reported hearing difficulty in older adults in the UK Biobank

Participants Impact MAF cutoff Variant load in normal hearing Variant load in hearing difficulty
Number of genes Deafness genes Highly variable genes Genes Deafness genes Highly variable genes
A
All High 0.005 23 2 (adj.p=1) 3 (adj.p=1) 29 7 (adj.p=8.95 × 10−4)* 4 (adj.p=0.98)
All High 0.01 28 2 (adj.p=1) 4 (adj.p=0.88) 54 9 (adj.p=0.0016)* 2 (adj.p=1)
All High 0.05 135 6 (adj.p=1) 15 (adj.p=0.021)* 116 15 (adj.p= 1.60 × 10−5)* 10 (adj.p=0.82)
All High 0.1 222 18 (adj.p=0.011)* 23 (adj.p= 0.0029)* 156 19 (adj.p= 2.38 × 10−5)* 12 (adj.p=1)
All High 0.2 347 24 (adj.p=0.014)* 35 (adj.p= 9.35 × 10−5)* 231 21 (adj.p= 6.92 × 10−4)* 24 (adj.p=0.0020)*
All High 1 635 32 (adj.p=0.29) 65 (adj.p= 3.32 × 10−9)* 630 39 (adj.p= 0.0031)* 72 (adj.p= 1.49 × 10−12)*
B
All Low 0.1 61 5 (adj.p=1) 9 (adj.p=0.033)* 36 0 (adj.p=1) 8 (adj.p=0.0035)*
C
Male High 0.1 181 17 (adj.p=7.67 × 10−4)* 15 (adj.p=0.099) 156 9 (adj.p=0.56) 8 (adj.p=1)
Female High 0.1 184 15 (adj.p=0.0086)* 16 (adj.p=0.052) 158 20 (adj.p= 1.87 × 10−6)* 13 (adj.p=0.16)
D
All High (MSC) 0.1 27 4 (adj.p=1) 7 (adj.p=1.88 × 10−4)* 11 4 (adj.p=0.21) 2 (adj.p=0.57)
Male High (MSC 0.1 14 2 (adj.p=1) 5 (adj.p=6.12 × 10−4)* 18 4 (adj.p=1) 6 (adj.p=1.60 × 10−4)*
Female High (MSC) 0.1 13 1 (adj.p=1) 2 (adj.p=0.77) 8 3 (adj.p=0.45) 3 (adj.p=0.020)*
  1. Significant p values (adj. p<0.05) are indicated with a *