Fig. 2

Single-cell analyses of SP140 expression in inflamed and uninflamed CD ileum. Publicly available single-cell RNA sequencing [24] was used to illustrate SP140 expression in intestinal (ileum) macrophages in inflamed (n=11) and uninflamed (n=11) tissue CD patients. a Marker genes expression per cell type where the size of the dots represents the percentage of cells expressing the gene. Darker blue represents more reads per cell. b UMAP of all the cells annotated with their annotated cell type. c Visual illustration of SP140 expression in all cells. Darker blue represents more reads per cell. d Visual illustration of the actual counts of SP140 expression in cluster 6 (MNPs). Darker blue represents more reads per cell. e Comparative analyses of the percentage cells expressing SP140 when comparing inflamed with uninflamed in different immune cells